Long term follow-up of infliximab efficacy in pulmonary and extra-pulmonary sarcoidosis refractory to conventional therapy.
Identifieur interne : 001114 ( Main/Exploration ); précédent : 001113; suivant : 001115Long term follow-up of infliximab efficacy in pulmonary and extra-pulmonary sarcoidosis refractory to conventional therapy.
Auteurs : Eric Russell [États-Unis] ; Francis Luk ; Sonia Manocha ; Tung Ho ; Carolyn O'Connor ; Humaira HussainSource :
- Seminars in arthritis and rheumatism [ 1532-866X ] ; 2013.
Descripteurs français
- KwdFr :
- MESH :
- traitement médicamenteux : Sarcoïdose, Sarcoïdose pulmonaire.
- usage thérapeutique : Anticorps monoclonaux.
- Adulte, Adulte d'âge moyen, Femelle, Humains, Infliximab, Mâle, Reprise du traitement, Résultat thérapeutique, Sujet âgé, Études de suivi.
English descriptors
- KwdEn :
- MESH :
- chemical , therapeutic use : Antibodies, Monoclonal.
- drug therapy : Sarcoidosis, Sarcoidosis, Pulmonary.
- Adult, Aged, Female, Follow-Up Studies, Humans, Infliximab, Male, Middle Aged, Retreatment, Treatment Outcome.
Abstract
Infliximab, a humanized, chimeric, monoclonal antibody against tumor necrosis alpha (TNF-α), has been shown to reduce the pulmonary and extra-pulmonary manifestations of sarcoidosis, however, there is little information regarding sustained efficacy with long-term use of infliximab. We retrospectively investigate whether a reduction in disease response is maintained, over a prolonged course of therapy (up to 85 months) with infliximab, and report on adverse events associated with its use.
DOI: 10.1016/j.semarthrit.2012.10.008
PubMed: 23332903
Affiliations:
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Le document en format XML
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USA. ERussell@ChristianaCare.org</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Delaware</region></placeName><wicri:cityArea>Christiana Care Rheumatology Department,Wilmington</wicri:cityArea></affiliation></author><author><name sortKey="Luk, Francis" sort="Luk, Francis" uniqKey="Luk F" first="Francis" last="Luk">Francis Luk</name></author><author><name sortKey="Manocha, Sonia" sort="Manocha, Sonia" uniqKey="Manocha S" first="Sonia" last="Manocha">Sonia Manocha</name></author><author><name sortKey="Ho, Tung" sort="Ho, Tung" uniqKey="Ho T" first="Tung" last="Ho">Tung Ho</name></author><author><name sortKey="O Connor, Carolyn" sort="O Connor, Carolyn" uniqKey="O Connor C" first="Carolyn" last="O'Connor">Carolyn O'Connor</name></author><author><name sortKey="Hussain, Humaira" sort="Hussain, Humaira" uniqKey="Hussain H" first="Humaira" last="Hussain">Humaira Hussain</name></author></analytic><series><title level="j">Seminars in arthritis and rheumatism</title><idno type="eISSN">1532-866X</idno><imprint><date when="2013" type="published">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Aged</term><term>Antibodies, Monoclonal (therapeutic use)</term><term>Female</term><term>Follow-Up Studies</term><term>Humans</term><term>Infliximab</term><term>Male</term><term>Middle Aged</term><term>Retreatment</term><term>Sarcoidosis (drug therapy)</term><term>Sarcoidosis, Pulmonary (drug therapy)</term><term>Treatment Outcome</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Anticorps monoclonaux (usage thérapeutique)</term><term>Femelle</term><term>Humains</term><term>Infliximab</term><term>Mâle</term><term>Reprise du traitement</term><term>Résultat thérapeutique</term><term>Sarcoïdose (traitement médicamenteux)</term><term>Sarcoïdose pulmonaire (traitement médicamenteux)</term><term>Sujet âgé</term><term>Études de suivi</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Antibodies, Monoclonal</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Sarcoidosis</term><term>Sarcoidosis, Pulmonary</term></keywords><keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Sarcoïdose</term><term>Sarcoïdose pulmonaire</term></keywords><keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Anticorps monoclonaux</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Aged</term><term>Female</term><term>Follow-Up Studies</term><term>Humans</term><term>Infliximab</term><term>Male</term><term>Middle Aged</term><term>Retreatment</term><term>Treatment Outcome</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Femelle</term><term>Humains</term><term>Infliximab</term><term>Mâle</term><term>Reprise du traitement</term><term>Résultat thérapeutique</term><term>Sujet âgé</term><term>Études de suivi</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Infliximab, a humanized, chimeric, monoclonal antibody against tumor necrosis alpha (TNF-α), has been shown to reduce the pulmonary and extra-pulmonary manifestations of sarcoidosis, however, there is little information regarding sustained efficacy with long-term use of infliximab. We retrospectively investigate whether a reduction in disease response is maintained, over a prolonged course of therapy (up to 85 months) with infliximab, and report on adverse events associated with its use.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Delaware</li></region></list><tree><noCountry><name sortKey="Ho, Tung" sort="Ho, Tung" uniqKey="Ho T" first="Tung" last="Ho">Tung Ho</name><name sortKey="Hussain, Humaira" sort="Hussain, Humaira" uniqKey="Hussain H" first="Humaira" last="Hussain">Humaira Hussain</name><name sortKey="Luk, Francis" sort="Luk, Francis" uniqKey="Luk F" first="Francis" last="Luk">Francis Luk</name><name sortKey="Manocha, Sonia" sort="Manocha, Sonia" uniqKey="Manocha S" first="Sonia" last="Manocha">Sonia Manocha</name><name sortKey="O Connor, Carolyn" sort="O Connor, Carolyn" uniqKey="O Connor C" first="Carolyn" last="O'Connor">Carolyn O'Connor</name></noCountry><country name="États-Unis"><region name="Delaware"><name sortKey="Russell, Eric" sort="Russell, Eric" uniqKey="Russell E" first="Eric" last="Russell">Eric Russell</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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